Anyone can hold a huppah pole. There’s no Jewish law on this. Unless your wedding officiant limits who can hold the huppah poles, or your community has strong expectations that you want to meet, you can choose anyone you want.
For my own wedding, for example, which was an Orthodox ceremony, we had both men and women holding poles. Some of the huppah bearers were Jewish and some were not Jewish. In fact, asking someone who is not Jewish to hold a huppah pole can be a great way to include them in your wedding if your officiant requires that the other roles in the ceremony, such as reciting a blessing, be done only be someone who is Jewish.